Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion

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Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion.

Portal infusion of glucose in the mouse at a rate equivalent to basal endogenous glucose production causes hypoglycemia, whereas peripheral infusion at the same rate causes significant hyperglycemia. We used tracer and arteriovenous difference techniques in conscious 42-h-fasted dogs to determine their response to the same treatments. The studies consisted of three periods: equilibration (100 m...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism

سال: 2004

ISSN: 0193-1849,1522-1555

DOI: 10.1152/ajpendo.00343.2003